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Germ Cell Drivers: Transmission of Preconception Stress Across Generations

Frontiers
Emerging evidence primarily from preclinical models suggests that epigenetic programming may encode preconception stress exposures in germ cells.
3 months ago

Preconceptional smoking alters spermatozoal miRNAs of murine fathers and affects offspring’s body weight

Nature
Active smoking has been reported among 7% of teenagers worldwide, with ages ranging from 13 to 15 years. An epidemiological study suggested...
40 months ago

Dysregulated miR-124 mediates impaired social memory behavior caused by paternal early social isolation

Nature
This study has discovered that paternal early SI causes social memory deficits and anxiety-like behavior in F1 young adult mice.
2 weeks ago

Prenatal paternal anxiety symptoms predict child DHEA levels and internalizing symptoms during adrenarche

Frontiers
IntroductionThis study examined (1) whether measures of paternal anxious and depressive symptoms collected prenatally and during a follow-up assessment when...
3 months ago

Reproductive tract extracellular vesicles are sufficient to transmit intergenerational stress and program neurodevelopment

Nature
We report reproductive tract EVs transmit information regarding stress in the paternal environment to sperm, potentially altering fetal development.
54 months ago

Parental experiences orchestrate locust egg hatching synchrony by regulating nuclear export of precursor miRNA

Nature
Here, we find that transcription factor Forkhead box protein N1 (FOXN1) responds to high population density and activates the polypyrimidine tract-binding...
4 months ago

Limitations to intergenerational inheritance: subchronic paternal stress preconception does not influence offspring anxiety

Nature
We report that subchronic CORT treatment of male breeders reduced their week-on-week body weight gain and altered NR3C1 and CRH gene expression in the...
48 months ago

Reduced levels of miRNAs 449 and 34 in sperm of mice and men exposed to early life stress | Translational Psychiatry

Nature
Exposure of male mice to early life stress alters the levels of specific sperm miRNAs that promote stress-associated behaviors in their offspring.
76 months ago

A next-generation sequencing study on mechanisms by which restraint and social instability stresses of male mice alter offspring anxiety-like behavior

Nature
Pathophysiological mechanisms for depression/anxiety are largely unknown. Evidence for transgenerational transmission of acquired epigenetic...
42 months ago

From Sperm Motility to Sperm-Borne microRNA Signatures: New Approaches to Predict Male Fertility Potential

Frontiers
In addition to the paternal genome, spermatozoa carry several intrinsic factors, including organelles (e.g., centrioles and mitochondria) and molecules...
3 months ago