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Alterations in sperm long RNA contribute to the epigenetic inheritance of the effects of postnatal trauma
Nature
Psychiatric diseases have a strong heritable component known to not be restricted to DNA sequence-based genetic inheritance alone but to...
72 months ago
From Sperm Motility to Sperm-Borne microRNA Signatures: New Approaches to Predict Male Fertility Potential
Frontiers
In addition to the paternal genome, spermatozoa carry several intrinsic factors, including organelles (e.g., centrioles and mitochondria) and molecules...
4 months ago
Parental life events cause behavioral difference among offspring: Adult pre-gestational restraint stress reduces anxiety across generations
Nature
Adult pre-gestational restraint reduced offspring's anxiety across generations; different stressors on parents may cause different phenotypes in offspring.
94 months ago
Exposure to childhood abuse is associated with human sperm DNA methylation | Translational Psychiatry
Nature
Offspring of persons exposed to childhood abuse are at higher risk of neurodevelopmental and physical health disparities across the life...
73 months ago
Exercise alters mouse sperm small noncoding RNAs and induces a transgenerational modification of male offspring conditioned fear and anxiety | Translational Psychiatry
Nature
There is growing evidence that the preconceptual lifestyle and other environmental exposures of a father can significantly alter the...
90 months ago
Fetal alcohol spectrum disorders and their transmission through genetic and epigenetic mechanisms
Frontiers
Fetal alcohol spectrum disorders (FASD) are a group of related conditions that arise from prenatal exposure to maternal consumption of the teratogen, ethanol.
8 months ago
The effects of di-butyl phthalate exposure from medications on human sperm RNA among men
Nature
Endocrine disruptors, such as phthalates, are suspected of affecting reproductive function. The Mesalamine and Reproductive Health Study...
62 months ago
Paternal cholestasis exacerbates obesity-associated hypertension in male offspring but is prevented by paternal ursodeoxycholic acid treatment
Nature
Obesity is a heterogeneous phenotype and risk associations to non-communicable diseases such as cardiovascular disease and type 2 diabetes...
77 months ago
Pre-reproductive stress in adolescent female rats alters oocyte microRNA expression and offspring phenotypes: pharmacological interventions and putative mechanisms
Nature
Pre-reproductive stress (PRS) to adolescent female rats alters anxiogenic behavior in first (F1)- and second-generation (F2) offspring and increases mRNA...
45 months ago
Epigenetic and transgenerational mechanisms in infection-mediated neurodevelopmental disorders
Nature
Prenatal infection is an environmental risk factor for various brain disorders with neurodevelopmental components, including autism spectrum disorder and...
90 months ago